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The gene expression profile in hepatic cholesterol metabolism was also changed (Fig

Although oral dosing may be a more appealing option versus parenteral administration for many patients and prescribing physicians [1216], mAbs are not amenable to oral dosing because they are prone to proteolysis and denaturation by gastrointestinal (GI) enzymes and generally have limited membrane permeability due to their large molecular weight (approximately 150 kDa) [1719]

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This cold-chain requirement adds substantial cost, limits distribution to pharmacies with adequate cold storage capacity, and creates logistical challenges in resource-limited settings and during natural disasters or supply chain disruptions

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